c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve.

@article{Hermann2001cFosGI,
  title={c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve.},
  author={Gerlinda E Hermann and Gregory S Emch and C. Amy Tovar and Richard C. Rogers},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={280 1},
  pages={R289-99}
}
The present study used activation of the c-Fos oncogene protein within neurons in the dorsal vagal complex (DVC) as a marker of neuronal excitation in response to systemic endotoxin challenge [i.e. , lipopolysaccharide (LPS)]. Specifically, we investigated whether vagal connections with the brain stem are necessary for LPS cytokine- induced activation of DVC neurons. Systemic exposure to LPS elicited a significant activation of c-Fos in neurons in the nucleus of the solitary tract (NST) and… CONTINUE READING

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