c-Fos associates with the endoplasmic reticulum and activates phospholipid metabolism.

@article{Bussolino2001cFosAW,
  title={c-Fos associates with the endoplasmic reticulum and activates phospholipid metabolism.},
  author={Daniela Fernanda Bussolino and Mario E Guido and Germ{\'a}n A. Gil and Graciela A. Borioli and Marianne L. Renner and Viviana R. Grabois and Cecilia B. Conde and Beatriz L. Caputto},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 3},
  pages={556-8}
}
c-Fos, a transcription factor that constitutes DNA-binding AP-1 complexes, regulates gene expression that promotes long-lasting cellular changes. We show that, in addition to its transcription factor activity, c-Fos regulates the metabolism of phospholipids cytoplasmically by an AP-1-independent activity. Two waves of c-Fos expression that promote subsequent waves of stimulation of 32P-orthophosphate incorporation into phospholipids are evidenced in quiescent cultured fibroblasts induced to re… CONTINUE READING

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