c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?

@article{Gao2009cFosAP,
  title={c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?},
  author={Yong-Jing Gao and Rongrong Ji},
  journal={The open pain journal},
  year={2009},
  volume={2},
  pages={11-17}
}
c-Fos, the protein of the protooncogene c-fos, has been extensively used as a marker for the activation of nociceptive neurons in the spinal cord for more than twenty years since Hunt et al. first reported that peripheral noxious stimulation to a hind paw of rats leads to a marked induction of c-Fos in superficial and deep dorsal horn neurons in 1987. In 1999, Ji et al. reported that phosphorylated extracellular signal-regulated kinase (pERK) is specifically induced by noxious stimulation in… CONTINUE READING

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Gereau RW receptor subtypes 1 and 5 are activators of extracellular signalregulated kinase signaling required for inflammatory pain in mice

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