c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.

@article{HinshawMakepeace2008cFLIPSRA,
  title={c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.},
  author={Jennifer A Hinshaw-Makepeace and Gail E. Huston and Karen A. Fortner and Jennifer Q. Russell and Daniel Holoch and Susan L Swain and Ralph C. Budd},
  journal={European journal of immunology},
  year={2008},
  volume={38 1},
  pages={54-63}
}
Effective stimulation of NF-kappaB in T cells following TCR ligation requires the activity of caspase-8. The active caspase-8 complex includes the paracaspase, MALT1, and Bcl-10, which connect to the NF-kappaB pathway. It has been less clear what regulates the level of caspase-8 activity during T cell activation. A likely candidate is cellular FLIP (c-FLIP), an enzymatically inert caspase-8 homologue. Two alternatively spliced forms of c-FLIP exist, a long form (c-FLIP(L)) and a short-form (c… CONTINUE READING
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