c-Cbl regulates αPix-mediated cell migration and invasion.

  title={c-Cbl regulates αPix-mediated cell migration and invasion.},
  author={Min Woo Seong and Ji Ho Park and Hee Min Yoo and Seung Wook Yang and Kyu Hee Oh and Seung Hyeun Ka and Dong Eun Park and Sang Kun Lee and Chin Ha Chung},
  journal={Biochemical and biophysical research communications},
  volume={455 3-4},
c-Cbl, a RING-type ubiquitin E3 ligase, down-regulates receptor tyrosine kinases, including EGF receptor, and inhibits cell proliferation. Moreover, c-Cbl mutations are frequently found in patients with myeloid neoplasm. Therefore, c-Cbl is known as a tumor suppressor. αPix is expressed only in highly proliferative and mobile cells, including immune cells, and up-regulated in certain invasive tumors, such as glioblastoma multiforme. Here, we showed that c-Cbl serves as an ubiquitin E3 ligase… CONTINUE READING