c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.

@article{Song2010cCblmediatedDO,
  title={c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.},
  author={Jae Jin Song and Miroslaw J Szczepanski and So Young Kim and Joo Hang Kim and Jee Young An and Yong Tae Kwon and Marco A Alcala and David L. Bartlett and Yong Joo Lee},
  journal={Cellular signalling},
  year={2010},
  volume={22 3},
  pages={553-63}
}
We previously reported two modes of development of acquired TRAIL resistance: early phase and late phase [1]. In these studies, we observed that greater Akt activity and the expression of Bcl-xL were related mainly to the late phase of acquired TRAIL resistance. Recently we became aware of a possible mechanism of early phase TRAIL resistance development through internalization and degradation of TRAIL receptors (DR4 and DR5). Our current studies demonstrate that TRAIL receptors rapidly diminish… CONTINUE READING

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