c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

@article{Naramura2002cCblAC,
  title={c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation},
  author={Mayumi Naramura and Ihn-Kyung Jang and Hemanta K. Kole and Fang Huang and Diana C. Haines and Hua Gu},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={1192-1199}
}
How Cbl family proteins regulate T cell responses is unclear. We found that c-Cbl Cbl-b double knock-out (dKO) T cells became hyperresponsive upon anti-CD3 stimulation, even though the major T cell antigen receptor (TCR) signaling pathways were not enhanced. The dKO T cells did not down-modulate surface TCR after ligand engagement, which resulted in sustained TCR signaling. However, these cells showed normal ligand-independent TCR internalization, and trafficking of internalized TCR to the… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
154 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 154 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

T cell receptor signaling precedes immunological synapse formation

  • Lee, K.-H
  • Science 295,
  • 2002

Similar Papers

Loading similar papers…