c-Abl downregulates the slow phase of double-strand break repair

@inproceedings{Meltser2010cAblDT,
  title={c-Abl downregulates the slow phase of double-strand break repair},
  author={Valentin Meltser and Merav Ben-Yehoyada and Nina Reuven and Yosef Shaul},
  booktitle={Cell Death and Disease},
  year={2010}
}
c-Abl tyrosine kinase is activated by agents that induce double-strand DNA breaks (DSBs) and interacts with key components of the DNA damage response and of the DSB repair machinery. However, the functional significance of c-Abl in these processes, remained unclear. In this study, we demonstrate, using comet assay and pulsed-field gel electrophoresis, that c-Abl inhibited the repair of DSBs induced by ionizing radiation, particularly during the second and slow phase of DSB repair… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Role of c-Abl in the DNA damage stress response

Yosef SHAUL, Merav BEN-YEHOYADA
  • Cell Research
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

p53: traffic cop at the crossroads of DNA repair and recombination

  • Nature Reviews Molecular Cell Biology
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

c-Abl: activation and nuclear targets

  • Cell Death and Differentiation
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL