bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina.

@article{Hildebrand2004bryAAU,
  title={bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina.},
  author={Mark Hildebrand and Laura E. Waggoner and Haibin Liu and Sebastian Sudek and Scott L Allen and Christine K. Anderson and David H. Sherman and Margo G. Haygood},
  journal={Chemistry & biology},
  year={2004},
  volume={11 11},
  pages={1543-52}
}
"Candidatus Endobugula sertula," the uncultivated bacterial symbiont of Bugula neritina, is the proposed source of the bryostatin family of anticancer compounds. We cloned a large modular polyketide synthase (PKS) gene complex from "Candidatus Endobugula sertula" and characterized one gene, bryA, which we propose is responsible for the initial steps of bryostatin biosynthesis. Typical PKS domains are present. However, acyltransferase domains are lacking in bryA, and beta-ketoacyl synthase… CONTINUE READING