brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

@article{Minami1999brinkerIA,
  title={brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes},
  author={Maki Minami and Noriyuki Kinoshita and Yuko Kamoshida and Hiromu Tanimoto and Tetsuya Tabata},
  journal={Nature},
  year={1999},
  volume={398},
  pages={242-246}
}
Growth and patterning of the Drosophila wing is controlled in part by the long-range organizing activities of the Decapentaplegic protein (Dpp)1,2,3,4. Dpp is synthesized by cells that line the anterior side of the anterior/posterior compartment border of the wing imaginal disc. From this source, Dpp is thought to generate a concentration gradient that patterns both anterior and posterior compartments. Among the gene targets that it regulates are optomotor blind (omb)5, spalt (sal)6, and… CONTINUE READING

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