brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2.

@article{Tamkun1992brahmaAR,
  title={brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2.},
  author={John W. Tamkun and Renate Deuring and Matthew P Scott and Mark Kissinger and A M Pattatucci and Thomas C Kaufman and James A. Kennison},
  journal={Cell},
  year={1992},
  volume={68 3},
  pages={
          561-72
        }
}
The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brm gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible… CONTINUE READING
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