bind to the RNA polymerase II CTD . Splicing and transcription-associated

  title={bind to the RNA polymerase II CTD . Splicing and transcription-associated},
  author={Andrew Emili and Michael Shales and Susan McCracken and Weijun Xie and Philip W. Tucker and Ryuji Kobayashi and Benjamin J. Blencowe and C. James Ingles},
The carboxyl-terminal domain (CTD) of the largest subunit of eukaryotic RNA polymerase II (pol II) plays an important role in promoting steps of pre-mRNA processing. To identify proteins in human cells that bind to the CTD and that could mediate its functions in pre-mRNA processing, we used the mouse CTD expressed in bacterial cells in affinity chromatography experiments. Two proteins present in HeLa cell extract, the splicing and transcription-associated factors, PSF and p54 nrb/NonO, bound… CONTINUE READING


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