beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.

@article{Shah2000beta3AN,
  title={beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.},
  author={Bhaval S. Shah and Edward B. Stevens and Mar{\'i}a Isabel Deniz Gonz{\'a}lez and Steven T. Bramwell and Robert Durham Pinnock and Kevin Y Lee and Alistair Kerr Dixon},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 11},
  pages={
          3985-90
        }
}
Adult dorsal root ganglia (DRG) have been shown to express a wide range of voltage-gated sodium channel alpha-subunits. However, of the auxiliary subunits, beta1 is expressed preferentially in only large- and medium-diameter neurons of the DRG while beta2 is absent in all DRG cells. In view of this, we have compared the distribution of beta1 in rat DRG and spinal cord with a novel, recently cloned beta1-like subunit, beta3. In situ hybridization studies demonstrated high levels of beta3 mRNA in… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

The role of sodium channels in neuropathic pain.

  • Seminars in cell & developmental biology
  • 2006
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED