beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.

@article{Pavoine2003beta2AdrenergicSI,
  title={beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.},
  author={Catherine Pavoine and Niloufar Behforouz and Chantal Gauthier and Sabine le Gouvello and Françoise Roudot-Thoraval and Catherine Rucker Martin and Andr{\'e} Pawlak and Chlo{\'e} F{\'e}ral and Nicole Defer and R{\'e}mi Houel and Sandrine Magne and Aissata Amadou and Daniel Y Loisance and Philippe Duvaldestin and Françoise Pecker},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 5},
  pages={1117-25}
}
We have recently established that enhancement of intracellular calcium cycling and contraction in response to beta2-adrenergic receptor (beta2-AR) stimulation exclusively relies on the activation of the cytosolic phospholipase A2 (cPLA2) and arachidonic acid production, via a pertussis toxin-sensitive G protein (possibly Gi), in embryonic chick cardiomyocytes. We aimed to investigate the relevance of the beta2-AR/Gi/cPLA2 pathway in the human myocardium. In left ventricular biopsies obtained… CONTINUE READING

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