beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.

  title={beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.},
  author={Catherine Pavoine and Niloufar Behforouz and Chantal Gauthier and Sabine le Gouvello and Françoise Roudot-Thoraval and Catherine Rucker Martin and Andr{\'e} Pawlak and Chlo{\'e} F{\'e}ral and Nicole Defer and R{\'e}mi Houel and Sandrine Magne and Aissata Amadou and Daniel Y Loisance and Philippe Duvaldestin and Françoise Pecker},
  journal={Molecular pharmacology},
  volume={64 5},
We have recently established that enhancement of intracellular calcium cycling and contraction in response to beta2-adrenergic receptor (beta2-AR) stimulation exclusively relies on the activation of the cytosolic phospholipase A2 (cPLA2) and arachidonic acid production, via a pertussis toxin-sensitive G protein (possibly Gi), in embryonic chick cardiomyocytes. We aimed to investigate the relevance of the beta2-AR/Gi/cPLA2 pathway in the human myocardium. In left ventricular biopsies obtained… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 30 references

Adrenergic and muscarinic receptors in the human heart.

Pharmacological reviews • 1999
View 6 Excerpts
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TC Chenier, GW 2ndDorn, SB Liggett
Circ Res • 2000

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