beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.

@article{Nakada2010beta2AdrenergicRG,
  title={beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.},
  author={Taka-aki Nakada and James A Russell and John H. Boyd and Rosal{\'i}a Aguirre-Hern{\'a}ndez and Katherine R. Thain and Simone A. Thair and Emiri Nakada and Melissa K. McConechy and Keith R. Walley},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={181 2},
  pages={
          143-9
        }
}
RATIONALE The CysGlyGln haplotype of the beta(2)-adrenergic receptor gene (ADRB2) is functional and associated with altered responses to adrenergic agonists in patients with asthma. Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown. OBJECTIVES To determine whether genetic variation of ADRB2 influences outcome in septic shock. METHODS Two cohorts of patients with septic shock were studied: a single center (St. Paul's… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes.

  • American journal of respiratory and critical care medicine
  • 2005
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Septic pulmonary microvascular endothelial cell injury: role of alveolar macrophage NADPH oxidase.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2009
VIEW 2 EXCERPTS

Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection.

  • Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2008
VIEW 1 EXCERPT

Pharmacogenetics of the human beta-adrenergic receptors

MR Taylor
  • Pharmacogenomics J 2007;7:29–37
  • 2007