beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.

@article{Bronnikov1999beta1TB,
  title={beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.},
  author={Gennady E Bronnikov and Tore Bengtsson and Ludmilla Kramarova and Valeria Golozoubova and Barbara Cannon and Jan Nedergaard},
  journal={Endocrinology},
  year={1999},
  volume={140 9},
  pages={
          4185-97
        }
}
To explain the distinctive pharmacological profiles observed for adrenergic stimulation of cell proliferation (beta1) and cell differentiation (beta3), the adrenergic control of cAMP accumulation was investigated during brown adipocyte development. In preadipocytes, norepinephrine (NE) increased cAMP levels but the beta3-agonists BRL-37344 and CGP-12177 did not; in contrast, when the cells had differentiated into mature brown adipocytes, a large cAMP response to the beta3-agonists had emerged… CONTINUE READING

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