beta-subunits of Snf1 kinase are required for kinase function and substrate definition.

@article{Schmidt2000betasubunitsOS,
  title={beta-subunits of Snf1 kinase are required for kinase function and substrate definition.},
  author={Martin C Schmidt and Rhonda R. McCartney},
  journal={The EMBO journal},
  year={2000},
  volume={19 18},
  pages={
          4936-43
        }
}
The Snf1 kinase and its mammalian homolog, the AMP-activated protein kinase, are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a beta-subunit that mediates heterotrimer formation. Saccharomyces cerevisiae encodes three beta-subunit genes, SIP1, SIP2 and GAL83. Earlier studies suggested that these subunits may not be required for Snf1 kinase function. We show here that complete and precise deletion of all three beta-subunit genes inactivates the… CONTINUE READING

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