beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells.

@article{Ramanathan2000betaSM,
  title={beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells.},
  author={Krishnan Ramanathan and Timothy H Michael and Paul Albert Fuchs},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 5},
  pages={1675-84}
}
Electrical tuning confers frequency selectivity onto sensory hair cells in the auditory periphery of frogs, turtles, and chicks. The resonant frequency is determined in large part by the number and kinetics of large conductance, calcium-activated potassium (BK) channels. BK channels in hair cells are encoded by the alternatively spliced slo gene and may include an accessory beta subunit. Here we examine the origins of kinetic variability among BK channels by heterologous expression of avian… CONTINUE READING