beta-cyclodextrin derivatives, SBE4-beta-CD and HP-beta-CD, increase the oral bioavailability of cinnarizine in beagle dogs.

@article{Jrvinen1995betacyclodextrinDS,
  title={beta-cyclodextrin derivatives, SBE4-beta-CD and HP-beta-CD, increase the oral bioavailability of cinnarizine in beagle dogs.},
  author={Tomi J{\"a}rvinen and Kristiina J{\"a}rvinen and Nancy Schwarting and Valentino J. Stella},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 3},
  pages={295-9}
}
The absolute bioavailabilities (Fabs) of cinnarizine after oral administration as two modified beta-cyclodextrin (SBE4-beta-CD or HP-beta-CD) solutions, an aqueous suspension, and two capsules in fasted beagle dogs were determined. Cinnarizine was administered orally (25.0 mg) and intravenously (12.5 mg) to four dogs. Blood samples were drawn for 24.5 h postdosing, and cinnarizine levels in plasma were determined by HPLC with spectrofluorometric detection. Cinnarizine pharmacokinetics after iv… CONTINUE READING

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Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats.

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Prediction of oral absorption of cinnarizine--a highly supersaturating poorly soluble weak base with borderline permeability.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V • 2014

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