beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.

@article{Brabletz1999betacateninRT,
  title={beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.},
  author={T. Brabletz and Andreas Jung and Sait Dag and Falk Hlubek and Thomas W. Kirchner},
  journal={The American journal of pathology},
  year={1999},
  volume={155 4},
  pages={1033-8}
}
Most colorectal cancers have loss of function mutations in the adenomatosis polyposis coli (APC) tumor suppressor gene. This leads to accumulation of beta-catenin, which together with the DNA binding protein TCF-4 functions as a transcriptional activator. Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for autonomous proliferation of colon tumors. Here we report the identification of the matrix metalloproteinase MMP-7 as another target gene of… CONTINUE READING
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