beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.

  title={beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.},
  author={Christine M. M. Lee and Hyun S Shvartsman and Michael T. Deavers and Shao-chun Wang and Weiya Xia and Rosemarie E Schmandt and Diane C. Bodurka and E. Neely Atkinson and Anais Malpica and David M. Gershenson and M -C Hung and Karen H. Lu},
  journal={Gynecologic oncology},
  volume={88 3},
OBJECTIVE beta-Catenin has been previously associated with oncogenic activity in human cancers. We evaluated whether beta-catenin also plays a role in papillary serous ovarian neoplasms. METHODS Immunohistochemistry for beta-catenin was performed on the primary ovarian serous neoplasms of 105 women. Of these, 10 were low malignant potential (LMP) serous tumors, and 95 were serous cancers. Nuclear beta-catenin staining was correlated with grade of tumor and median survival. OVCAR-3, OVCA-420… CONTINUE READING


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