beta-catenin is a target for the ubiquitin-proteasome pathway.

  title={beta-catenin is a target for the ubiquitin-proteasome pathway.},
  author={Hermann Aberle and Andr{\'a}s Bauer and J{\"o}rg Stappert and Andreas Kispert and Rolf Kemler},
  journal={The EMBO journal},
  volume={16 13},
beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. beta… CONTINUE READING
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