beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.

@article{MartnMartnez2000betaTurnedDA,
  title={beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.},
  author={M. Mart{\'i}n-Mart{\'i}nez and N. de la Figuera and M. Latorre and R. Herranz and M. Garc{\'i}a-L{\'o}pez and E. Cenarruzabeitia and J. del R{\'i}o and R. Gonz{\'a}lez-Mu{\~n}iz},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 20},
  pages={
          3770-7
        }
}
To improve our knowledge of the bioactive conformation of CCK(1) antagonists, we previously described that replacement of the alpha-MeTrp residue of dipeptoids with the (2S,5S, 11bR)-2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carbox ylate (IBTM) skeleton, a probed type II' beta-turn mimetic, led to restricted analogues (2S,5S,11bR,1'S)- and (2S,5S,11bR, 1'R)-2-(benzyloxycarbonyl)amino-5-[1'-benzyl-2'-(carboxy)ethyl]carbam oyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole, 1a,b… Expand
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