beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.

@article{GkmenPolar2005betaTubulinMA,
  title={beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.},
  author={Yesim G{\"o}kmen-Polar and Daniel Escuin and Chad D. Walls and Sharon E. Soule and Yuefang Wang and Kerry L. Sanders and Theresa M Lavallee and Mu Zhong Wang and Brian D. Guenther and Paraskevi Giannakakou and George W. Sledge},
  journal={Cancer research},
  year={2005},
  volume={65 20},
  pages={9406-14}
}
2-Methoxyestradiol is an estradiol metabolite with significant antiproliferative and antiangiogenic activity independent of estrogen receptor status. To identify a molecular basis for acquired 2-methoxyestradiol resistance, we generated a stable 2-methoxyestradiol-resistant (2ME2R) MDA-MB-435 human cancer cell line by stepwise exposure to increasing 2-methoxyestradiol concentrations. 2ME2R cells maintained in the presence of the drug and W435 cells maintained in the absence of the drug showed… CONTINUE READING

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MS Poruchynsky, JH Kim, E Nogales
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