beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.

@article{Wong2005betaSO,
  title={beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.},
  author={Hon-Kit Wong and Takashi Sakurai and Fumitaka Oyama and Kumi Kaneko and Koji Wada and Haruko Miyazaki and Masaru Kurosawa and Bart De Strooper and Paul Saftig and Nobuyuki Nukina},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 24},
  pages={23009-17}
}
Sequential processing of amyloid precursor protein (APP) by membrane-bound proteases, BACE1 and gamma-secretase, plays a crucial role in the pathogenesis of Alzheimer disease. Much has been discovered on the properties of these proteases; however, regulatory mechanisms of enzyme-substrate interaction in neurons and their involvement in pathological changes are still not fully understood. It is mainly because of the membrane-associated cleavage of these proteases and the lack of information on… CONTINUE READING
102 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 102 extracted citations

Similar Papers

Loading similar papers…