beta -Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons.

@article{Cameron2001betaI,
  title={beta -Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons.},
  author={J. Spottiswoode Cameron and Laurence Dryer and Stuart E Dryer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 5},
  pages={
          2832-6
        }
}
The development of functional Ca(2+)-activated K(+) channels (K(Ca)) in chick ciliary ganglion (CG) neurons requires interactions with afferent preganglionic nerve terminals. Here we show that the essential preganglionic differentiation factor is an isoform of beta-neuregulin-1. beta-Neuregulin-1 transcripts are expressed in the midbrain preganglionic Edinger-Westphal nucleus at developmental stages that coincide with or precede the normal onset of macroscopic K(Ca) in CG neurons. Injection of… CONTINUE READING
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