beta-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle.

@article{Breen2006betaNADIA,
  title={beta-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle.},
  author={L. T. Breen and L. M. Smyth and I. Yamboliev and V. Mutafova-Yambolieva},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 2},
  pages={
          F486-95
        }
}
  • L. T. Breen, L. M. Smyth, +1 author V. Mutafova-Yambolieva
  • Published 2006
  • Medicine, Chemistry
  • American journal of physiology. Renal physiology
  • Endogenous nucleotides with extracellular functions may be involved in the complex neural control of human urinary bladder (HUB). Using HPLC techniques with fluorescence detection, we observed that in addition to ATP and its metabolites ADP, AMP and adenosine, electrical field stimulation (EFS; 4-16 Hz, 0.1 ms, 15 V, 60 s) of HUB detrusor smooth muscle coreleases novel nucleotide factors, which produce etheno-1N(6)-ADP-ribose (eADPR) on etheno-derivatization at high temperature. A detailed HPLC… CONTINUE READING
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    References

    SHOWING 1-10 OF 47 REFERENCES
    Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder.
    • 38
    Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.
    • H. C. Lee
    • Medicine, Biology
    • Annual review of pharmacology and toxicology
    • 2001
    • 413
    Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic cotransmission in the rat isolated tail artery
    • 51
    Purinoceptor desensitization impairs but does not abolish the non-cholinergic motor transmission in rat isolated urinary bladder.
    • 36
    Cyclic GMP-dependent and -independent Effects on the Synthesis of the Calcium Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate*
    • 103
    • PDF