beta-Lactam synthetase: a new biosynthetic enzyme.

  title={beta-Lactam synthetase: a new biosynthetic enzyme.},
  author={Brian O. Bachmann and Renhao Li and Craig A Townsend},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 16},
The principal cause of bacterial resistance to penicillin and other beta-lactam antibiotics is the acquisition of plasmid-encoded beta-lactamases, enzymes that catalyze hydrolysis of the beta-lactam bond and render these antibiotics inactive. Clavulanic acid is a potent inhibitor of beta-lactamases and has proven clinically effective in combating resistant infections. Although clavulanic acid and penicillin share marked structural similarities, the biosyntheses of their bicyclic nuclei are… CONTINUE READING
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