beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling.

Abstract

Wnt/beta-catenin signaling is an important regulator of cell polarity, proliferation, and stem cell maintenance during development and adulthood. Wnt proteins induce the nuclear accumulation of beta-catenin, which regulates the expression of Wnt-responsive genes through association with TCF/LEF transcription factors. Aberrant Wnt/beta-catenin signaling has… (More)
DOI: 10.1096/fj.09-141671

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