beta-Endorphin secretion of arginine vasopressin in vivo.


The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes compared to controls. In contrast beta-endorphin had no significant effect on AVP release from isolated rat neural lobes in vitro. beta-Endorphin stimulates AVP secretion in vivo, but this is not due to a direct action upon the neural lobe.

Cite this paper

@article{Weitzman1977betaEndorphinSO, title={beta-Endorphin secretion of arginine vasopressin in vivo.}, author={Richard E Weitzman and Delbert A. Fisher and Scott Minick and Nick Ling and Roger Guillemin}, journal={Endocrinology}, year={1977}, volume={101 5}, pages={1643-6} }