beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation.

@article{Conner1997betaArrestin1KM,
  title={beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation.},
  author={David A. Conner and Michael A. Mathier and Richard M. Mortensen and Michael E. Christe and Stephen F. Vatner and Christine E Seidman and Jon G. Seidman},
  journal={Circulation research},
  year={1997},
  volume={81 6},
  pages={1021-6}
}
beta-Arrestin1 knockout mice were studied to define the physiological role of beta-arrestin1 in the regulation of G protein-coupled receptors. beta-Arrestin1 is thought to be involved in the desensitization of many G protein-associated cell surface receptors, particularly beta-adrenergic receptors. Homozygous knockout mice are overtly normal. Resting cardiovascular parameters modulated by beta-adrenergic receptors such as heart rate, blood pressure, and left ventricular ejection fraction are… CONTINUE READING

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