beta-Amyloid peptide in vitro toxicity: lot-to-lot variability.

  title={beta-Amyloid peptide in vitro toxicity: lot-to-lot variability.},
  author={Patrick C. May and Bruce D Gitter and Dic Waters and L K Simmons and Gerald W. Becker and Jennifer S. Small and Philip Robison},
  journal={Neurobiology of aging},
  volume={13 5},
beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal cultures and found marked lot-to-lot differences in the neurotoxic properties of beta AP. One lot of beta AP from a commercial supplier resulted in significant direct… CONTINUE READING