beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent.

@article{Lorton1997betaAmyloidinducedIB,
  title={beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent.},
  author={Dianne Lorton},
  journal={Mechanisms of ageing and development},
  year={1997},
  volume={94 1-3},
  pages={199-211}
}
  • Dianne Lorton
  • Published 1997 in Mechanisms of ageing and development
The proinflammatory cytokine, interleukin-1 (IL-1) is elevated in the Alzheimer's disease (AD) brain. Studies from our laboratory have demonstrated that beta-amyloid (A beta) 1-42, fibrillar A beta 1-40 and A beta 25-35 induce the release of IL-1 beta from activated THP-1 cells, a human monocyte cell line. A beta also is chemotactic for primary rodent microglia and peritoneal macrophages. We hypothesize that A beta is a chemokine and induces these responses by interaction with chemotactic… CONTINUE READING

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