beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

@article{Pettit2001betaAmyloid142PD,
  title={beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.},
  author={Diana L. Pettit and Zuoyi Shao and Jerrel L Yakel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 1},
  pages={
          RC120
        }
}
Alzheimer's disease (AD) is a human neurological disorder characterized by an increasing loss of cognitive function and the presence of extracellular neuritic plaques composed of the beta-amyloid peptide (Abeta(1-42)). However, the link between these molecular correlates of AD and the loss of cognitive function has not been established. The pathology associated with AD includes the loss of basal forebrain cholinergic neurons, presynaptic terminals in the neocortex and hippocampus, and a… CONTINUE READING
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