beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.

@article{Derave2007betaAlanineSA,
  title={beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.},
  author={W. Derave and M. Ozdemir and R. Harris and A. Pottier and H. Reyngoudt and K. Koppo and J. Wise and E. Achten},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 5},
  pages={
          1736-43
        }
}
Carnosine (beta-alanyl-l-histidine) is present in high concentrations in human skeletal muscle. The ingestion of beta-alanine, the rate-limiting precursor of carnosine, has been shown to elevate the muscle carnosine content. We aimed to investigate, using proton magnetic resonance spectroscopy (proton MRS), whether oral supplementation with beta-alanine during 4 wk would elevate the calf muscle carnosine content and affect exercise performance in 400-m sprint-trained competitive athletes… Expand

Paper Mentions

Muscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs. untrained muscles.
TLDR
It is shown that carnosine content can be reliably measured by proton magnetic resonance spectroscopy by (1)H-MRS in deltoid muscle, and carnOSine loading is equally effective in arm vs. leg muscles of nonathletes and more pronounced in trained vs. untrained muscles. Expand
Carnosine loading and washout in human skeletal muscles.
TLDR
It can be concluded that carnosine is a stable compound in human skeletal muscle, confirming the absence of carnosinase in myocytes, and shows that washout periods for crossover designs in supplementation studies for muscle metabolites may sometimes require months rather than weeks. Expand
Important role of muscle carnosine in rowing performance.
TLDR
It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and thepositive correlation between changes in muscle Carnosine and performance improvement suggest that muscle carnOSine is a new determinant of roowing performance. Expand
Exercise Training and Beta-Alanine-Induced Muscle Carnosine Loading
TLDR
HV and HI exercise training showed no significant difference on BA-induced muscle carnosine loading in soleus and gastrocnemius muscle, and it can be suggested that there can be a small cumulative effect of exercise on BA supplementation efficiency. Expand
Doubling of muscle carnosine concentration does not improve laboratory 1-hr cycling time-trial performance.
TLDR
Chronic beta-alanine supplementation in well-trained cyclists had a very pronounced effect on muscle carnosine concentration and a moderate attenuating effect on the acidosis associated with lactate accumulation, yet without affecting 1-h time-trial performance under laboratory conditions. Expand
Role of beta-alanine supplementation on muscle carnosine and exercise performance.
TLDR
Beta-alanine supplementation seems to be a safe nutritional strategy capable of improving high-intensity anaerobic performance and delaying the onset of neuromuscular fatigue. Expand
Acute carnosine and β-alanine supplementation increases the compensated part of the ventilation vs work rate relationship during a ramp incremental cycle test in physically active men.
TLDR
A positive effect of acute Carn-ßA supplementation on the compensated part of the exercise is demonstrated, which should be taken into account by nutritionists and athletes searching for nutritional supplements, when a quick effect based on an acute dose is required. Expand
Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men
TLDR
Four weeks of BA supplementation improved isometric, but not isokinetic or isotonic endurance performance, although the effects of beta-alanine supplementation on strength endurance are equivocal. Expand
Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training
TLDR
Interestingly, muscle carnosine loading leads to improved performance in high-intensity exercise in both untrained and trained individuals, which suggests an important role of the dipeptide in the homeostasis of contracting muscle cells, especially during high rates of anaerobic energy delivery. Expand
β-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
TLDR
Results indicate that chronic β-alanine supplementation, which presumably increased muscle carnosine content, can attenuate the fall in blood pH during high-intensity exercise. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
TLDR
The increase in TWD with supplementation followed the increase in muscle carnosine, which was significantly increased by +58.8% and +80.1% after 4 and 10 wks β-alanine supplementation. Expand
High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.
TLDR
The results indicated that the carnosine concentration could be an important factor in determining the high-intensity exercise performance. Expand
Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.
TLDR
Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion. Expand
Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius.
TLDR
Study of the effect of sustained dietary beta-alanine supplementation in the horse on the carnosine concentration in types I, IIA and IIB skeletal muscle fibres found an adaptive response to sustained beta-aloine administration, and changes in muscle carnosines concentration appeared to be influenced by beta-Alanine bioavailability. Expand
Metabolic effects of induced alkalosis during progressive forearm exercise to fatigue.
TLDR
NaHCO(3) ingestion was shown to increase plasma pH at rest, which resulted in a delayed onset of intracellular acidification during incremental exercise, and was not associated with increased muscle phosphocreatine breakdown, muscle glycogen utilization, and plasma lactate accumulation. Expand
Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.
TLDR
The data suggest that a dietary-induced increase in muscle total Cr concentration can increase PCr resynthesis during the 2nd min of recovery from intense contraction. Expand
Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women
TLDR
β-alanine supplementation appears to improve submaximal cycle ergometry performance and time-to-exhaustion in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations. Expand
Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation.
TLDR
Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%. Expand
Blood lactate and ammonia in short-term anaerobic work following induced alkalosis.
TLDR
The altered relationship observed between blood lactate and ammonia under placebo and buffering loading conditions suggests that the regulation of lactateand ammonia metabolism is unrelated. Expand
The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis
TLDR
Plasma taurine was increased by β-alanine ingestion but this did not result in any increased loss via urine, and Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine. Expand
...
1
2
3
4
5
...