beta-Adrenergic receptor desensitization in rat adipocyte membranes.

  title={beta-Adrenergic receptor desensitization in rat adipocyte membranes.},
  author={Yves Giudicelli and Brigitte Agli and Danie le Lacasa},
  journal={Biochimica et biophysica acta},
  volume={585 1},
Abstract 1. 1. The ability of β-adrenergic agonists to inactivate the β-adrenergic receptors of rat while adipocytes has been investigated using (−)-[3H]dihydroalprenolol as the β-adrenergic ligand. 2. 2. When adipocyte membranes are successively exposed to (−)-isoproterenol at 25 or 4°C, repeatedly washed and then incubated with [3H]dihydroalprenolol, 40–60% of the β-receptors are lost. 3. 3. This loss (receptor desensitization) is rapid (half-life = 5–10 min), is concentration-dependent and… CONTINUE READING