beta(2)-Adrenoceptors and ventricular fibrillation.

  title={beta(2)-Adrenoceptors and ventricular fibrillation.},
  author={Ruth A. Altschuld and George E. Billman},
  journal={Pharmacology & therapeutics},
  volume={88 1},
beta-Adrenoceptor antagonists significantly reduce the incidence of sudden cardiac death in patients with contractile dysfunction. Contractile dysfunction is associated with a decline in beta(1)-adrenoceptors, no change in the number of beta(2)-adrenoceptors, and an increased responsiveness to beta(2)-adrenoceptor stimulation. Selective beta(2)-adrenoceptor blockade prevents ventricular fibrillation in a canine model of sudden cardiac death. Cardiac beta(2)-adrenoceptor stimulation increases L… CONTINUE READING

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