bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas.

@article{Smoller1994bcl2ER,
  title={bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas.},
  author={Bruce Robert Smoller and Matt van de Rijn and D Lebrun and Roger A. Warnke},
  journal={The British journal of dermatology},
  year={1994},
  volume={131 1},
  pages={28-31}
}
Trichoepitheliomas (TE) are benign follicular neoplasms which are frequently confused with basal cell carcinomas (BCC). It is important to distinguish these entities precisely, as the treatments and prognoses are different. To this end, we stained a series of formalin-fixed, paraffin-embedded specimens of unequivocal TE and BCC with antibodies directed against bcl-2, an oncogene associated with programmed cell death, and known to be overexpressed in some malignant tumours. The TE showed… CONTINUE READING