bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time.

@article{Ohsaki1996bcl2AP,
  title={bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time.},
  author={Yoshinobu Ohsaki and E Toyoshima and Satoru Fujiuchi and Hayato Matsui and Shitau Hirata and Naoyuki Miyokawa and Yoshiaki Kubo and Keiji Kikuchi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 5},
  pages={915-20}
}
Apoptosis-related genes have received increasing attention in carcinogenesis, drug sensitivity, radiation sensitivity, and patient survival. bcl-2 and mutated p53 genes have been reported to inhibit apoptosis. To determine bcl-2 and p53 protein expression and their impacts on survival time in lung cancers, we studied 99 surgically resected, paraffin-embedded non-small cell lung cancer (NSCLC) specimens by immunohistochemical staining. The bcl-2 protein was expressed in 19.2% of NSCLCs. bcl-2… CONTINUE READING

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