bcl-2 and p53 in endometrial adenocarcinoma.

@article{Taskin1997bcl2AP,
  title={bcl-2 and p53 in endometrial adenocarcinoma.},
  author={Metin Taskin and Thomas A. Lallas and Hugh R. K. Barber and Maria M. Shevchuk},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1997},
  volume={10 7},
  pages={
          728-34
        }
}
bcl-2 protein is expressed in normal endometrium and seems to be under hormonal control. Its role in endometrial carcinoma (EC) is largely unknown. EC can serve as a good model to investigate the role of bcl-2 in hormone-dependent neoplasia, because EC shows a spectrum of hormonally induced changes in which bcl-2 might have a potential role. p53, a tumor suppressor gene, is the most commonly mutated gene in human cancer and is a frequent abnormality in advanced EC. There is interaction between… CONTINUE READING

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