bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection.

@article{Zuckerman2001bcl2AI,
  title={bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection.},
  author={Eli Zuckerman and Tsila Zuckerman and Dvorah Sahar and Sara Streichman and Dominique Attias and Edmond Sabo and Daniel Yeshurun and Jacob M. Rowe},
  journal={British journal of haematology},
  year={2001},
  volume={112 2},
  pages={
          364-9
        }
}
An association between chronic hepatitis C virus (HCV) infection and clonal proliferation of B cells, including B cell lymphoma, has recently been demonstrated. However, the mechanism of malignant transformation is still unknown. It has been shown that B cells from patients with type II mixed cryoglobulinaemia (MC), strongly express the antiapoptotic bcl-2 oncogene product. Therefore, we investigated a possible mechanism of lymphomagenesis, the occurrence of bcl-2 and immunoglobulin gene… CONTINUE READING

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