• Corpus ID: 8199473

bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.

@article{Marone1998bcl2BB,
  title={bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.},
  author={Maria Marone and Giovanni Scambia and Simona Mozzetti and Gabriella Ferrandina and Sonia Marie Cattarinussi Iacovella and A de Pasqua and Pierluigi Benedetti‐Panici and S. Mancuso},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 2},
  pages={
          517-24
        }
}
  • M. Marone, G. Scambia, S. Mancuso
  • Published 1 February 1998
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
The bcl-2 family of proteins includes some important regulators of apoptosis. Among these, bcl-2 and bcl-xL prevent cells from entering apoptosis, whereas bax and bcl-xS can induce cell death. Alterations in the control of this process can lead to a decrease in cell death, thus contributing to neoplastic growth. Diminished susceptibility to chemotherapy has also been attributed, in in vitro systems, to alterations in the levels of bcl-2, bax, or bcl-x. We analyzed the expression of bcl-2, bax… 

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References

SHOWING 1-10 OF 57 REFERENCES
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.
TLDR
It is suggested that expression of several anti-apoptotic members of the bcl-2 gene family, including b cl-2, bcl -X, and mcl-1 increases during progression of prostate cancers, a finding that may be relevant to the hormone-insensitive, metastatic phenotype of most advanced adenocarcinomas of the prostate.
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL
TLDR
The data suggest that B cl-2 and Bcl-xL exert an anti-cell death function by a mechanism other than regulation of ROS activity.
The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma.
TLDR
Both p53 and Bcl-2 were found to be independent prognostic indicators of survival in ovarian cancer, and survival was poorer in patients with tumors expressing high levels of p53, whereas expression of B cl-2 was associated with improved survival.
The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2.
TLDR
Exogenous expression of Bcl-2 or a temperature sensitive mutant p53 in the ovarian cell line A2780 resulted in protection from drug-induced apoptosis and a delay in drug-mediated S-phase arrest and suggest that these genes are important determinants of drug- induced apoptosis thereby modulating resistance to chemotherapy.
bcl-2 protein in non-small-cell lung carcinoma.
TLDR
The proto-oncogene bcl-2 is abnormally expressed in some lung carcinomas, and its expression may have prognostic importance.
bcl‐2 Protein Expression in Cutaneous Malignant Melanoma and Benign Melanocytic Nevi
TLDR
The results indicate that bcl-2 protein expression is a common finding in cutaneous melanocytic lesions regardless of their biologic behavior, and Expression of the protein in the great majority of MM seems to exclude a prognostic significance of bCl-2 in MM of the skin.
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
TLDR
It is demonstrated that a temperature-sensitive p53 induces temperature-dependent decreases in the expression of the apoptosis-suppressing gene bcl-2 in the murine leukemia cell M1, while simultaneously stimulating increases in theexpression of bax, a gene which encodes a dominant-inhibitor of the Bcl-1 protein.
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.
TLDR
It is demonstrated that the levels of Mcl-1 and Bcl-2 proteins are differentially regulated in normal and neoplastic cells in lymph nodes and thus suggest different roles for these proteins in the control of cell life and death in these tissues.
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