Corpus ID: 8199473

bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.

@article{Marone1998bcl2BB,
  title={bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.},
  author={M. Marone and G. Scambia and S. Mozzetti and G. Ferrandina and S. Iacovella and A. De Pasqua and P. Benedetti-Panici and S. Mancuso},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 2},
  pages={
          517-24
        }
}
  • M. Marone, G. Scambia, +5 authors S. Mancuso
  • Published 1998
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • The bcl-2 family of proteins includes some important regulators of apoptosis. Among these, bcl-2 and bcl-xL prevent cells from entering apoptosis, whereas bax and bcl-xS can induce cell death. Alterations in the control of this process can lead to a decrease in cell death, thus contributing to neoplastic growth. Diminished susceptibility to chemotherapy has also been attributed, in in vitro systems, to alterations in the levels of bcl-2, bax, or bcl-x. We analyzed the expression of bcl-2, bax… CONTINUE READING
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    References

    SHOWING 1-10 OF 57 REFERENCES
    Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.
    • 606
    bcl-2 protein in non-small-cell lung carcinoma.
    • 547
    bcl‐2 Protein Expression in Cutaneous Malignant Melanoma and Benign Melanocytic Nevi
    • 99