bcl‐2 Translocation in Japanese B Cell Lyraphoma: Novel bcl‐2 Translocation with Immunoglobulin Heavy Chain Diversity Segment

Breakpoints of a lymphoma case with bcl-2 gene rearrangement that did not show comigration of immunoglobulin (Ig) heavy chain joining (JH) fragment were cloned. Sequence analysis revealed that the translocation broke the 3' side of the Ig heavy chain diversity (DH) segment at the heptamer recombination signal and each end was ligated to the bcl-2 locus… CONTINUE READING