bal Reactivation of Epigenetically Silenced Genes Pr R rostate Cancer

  title={bal Reactivation of Epigenetically Silenced Genes Pr R rostate Cancer},
  author={Ibragimova and Inmaculada Ib{\'a}{\~n}ez de C{\'a}ceres and Amanda M. Hoffman and Anna Potapova and Dulaimi and T Al-saleem and Gary R. Hudes and Michael F. Ochs and Paul Cairns},
wnloaded nscriptional silencing associated with aberrant promoter hypermethylation is a common anism of inactivation of tumor suppressor genes in cancer cells. To globally profile the genes ed by hypermethylation in prostate cancer, we screened a whole genome expression microarray nes reactivated in the LNCaP, DU-145, PC-3, and MDA2b prostate tumor cell lines after treatment the demethylating drug 5-aza-2-deoxycytidine and the histone deacetylation–inhibiting drug statin A. A total of 2,997… CONTINUE READING
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