bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells

  title={bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells},
  author={Itaru Imayoshi and Ryoichiro Kageyama},
Multipotent neural progenitor cells (NPCs) undergo self-renewal while producing neurons, astrocytes, and oligodendrocytes. These processes are controlled by multiple basic helix-loop-helix (bHLH) fate determination factors, which exhibit different functions by posttranslational modifications. Furthermore, depending on the expression dynamics, each bHLH factor seems to have two contradictory functions, promoting NPC proliferation and cell-cycle exit for differentiation. The oscillatory… CONTINUE READING
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