bFGF induces differentiation and death of olfactory neuroblastoma cells.

@article{Nibu2000bFGFID,
  title={bFGF induces differentiation and death of olfactory neuroblastoma cells.},
  author={Ken-Ichi Nibu and Gang Li and Kichizo Kaga and Jay L. Rothstein},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={279 1},
  pages={172-80}
}
Olfactory neuroblastoma (ONB) is a highly vascularized and malignant tumor arising in olfactory neuronal precursors from the paranasal sinuses. Previously, we showed that treatment of JFEN cells with transforming growth factor (TGF)-alpha caused them to differentiate and respond to chemical odorants, whereas basic fibroblast growth factor (bFGF) treated cells differentiated and died. In the present study we show that established ONB tumors treated with bFGF upregulate the bFGF receptor (FGFR1… CONTINUE READING