b-and g-Catenin Mutations , but not E-Cadherin Inactivation , Underlie T-Cell Factor / Lymphoid Enhancer Factor Transcriptional Deregulation in Gastric and Pancreatic Cancer 1

@inproceedings{Caca1999bandGM,
  title={b-and g-Catenin Mutations , but not E-Cadherin Inactivation , Underlie T-Cell Factor / Lymphoid Enhancer Factor Transcriptional Deregulation in Gastric and Pancreatic Cancer 1},
  author={Karel Caca and Frank Thomas Kolligs and Xiaodong Ji and Marianne K. Hayes and Jia-ming Qian and Alan I Yahanda and David L. Rimm and Jos{\'e} Sebasti{\'a}n D{\'a}vila Costa and Eric R. Fearon},
  year={1999}
}
Adenomatous polyposis coli (APC) mutations are present in >70% of colon cancers. The APC protein binds to b-catenin (b-cat), a protein first identified because of its role in E-cadherin (E-cad) cell adhesion. In some colon cancers lacking APC defects, mutations in presumptive glycogen synthase kinase 3b phosphorylation sites near the b-cat NH2 terminus appear to render b-cat resistant to regulation by APC and glycogen synthase kinase 3b. In cells with APC or b-cat defects, b-cat is stabilized… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…