b-Amyloid peptide blocks the response of a 7-containing nicotinic receptors on hippocampal neurons

@inproceedings{Liu2001bAmyloidPB,
  title={b-Amyloid peptide blocks the response of a 7-containing nicotinic receptors on hippocampal neurons},
  author={Qing-Song Liu and Hideki Kawai and Darwin K. Berg},
  year={2001}
}
Alzheimer’s disease produces a devastating decline in mental function, with profound effects on learning and memory. Early consequences of the disease include the specific loss of cholinergic neurons in brain, diminished cholinergic signaling, and the accumulation of b-amyloid peptide in neuritic plaques. Of the nicotinic acetylcholine receptors at risk, the most critical may be those containing the a7 gene product (a7-nAChRs), because they are widespread, have a high relative permeability to… CONTINUE READING
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