b-Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT y enhancer-binding protein d

@inproceedings{Colangelo1998bAdrenergicRA,
  title={b-Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT y enhancer-binding protein d},
  author={Anna Maria Colangelo and Peter Frederick Johnson and Italo Mocchetti},
  year={1998}
}
Stimulation of b-adrenergic receptors (BAR) by clenbuterol (CLE) increases nerve growth factor (NGF) biosynthesis in the rat cerebral cortex but not in other regions of the brain. We have explored the transcription mechanisms that may account for the cortex-specific activation of the NGF gene. Although the NGF promoter contains an AP-1 element, AP-1-binding activity in the cerebral cortex was not induced by CLE, suggesting that other transcription factors govern the brain area-specific… CONTINUE READING
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