atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB.

@article{Drysdale2004atxACB,
  title={atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB.},
  author={Melissa Drysdale and Agathe Bourgogne and Susan G. Hilsenbeck and Theresa M Koehler},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 2},
  pages={
          307-15
        }
}
Two regulatory genes, acpA and atxA, have been reported to control expression of the Bacillus anthracis capsule biosynthesis operon capBCAD. The atxA gene is located on the virulence plasmid pXO1, while pXO2 carries acpA and the cap genes. acpA has been viewed as the major regulator of the cap operon because it is essential for capsule gene expression in a pXO1(-) pXO2(+) strain. atxA is essential for toxin gene transcription but has also been implicated in control of the cap genes. The… CONTINUE READING

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